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November 25, 2019 3 min read

At Meraki Tips we are all about celebrating the wonderful science that is terpenes, which is an aspect of cannabis that more and more consumers are delving into. Earlier, we covered limonene, where we noted the various applications under which this terpene is finding a valuable place in cannabinoid and medical science. 

This time we’re focusing in on another incredible, yet lesser-known terpene: trans-nerolidol.

Terpenes Refresher

As a refresher, terpenes, such as limonene and nerolidol, are essential oils that are produced in the resin glands of the cannabis flowers and are largely responsible for the aroma and flavor of individual cannabis strains. Essential oils are volatile, natural and complex bioactive compounds which are known to be associated to a series of complex interactions with cells, tissues and whole organisms.

Terpenes also act in conjunction with cannabinoids and flavonoids to enhance the effects on each other. This phenomenon is known as the “Entourage Effect”, which was discovered by Dr. Ralph Mechoulam and Dr. Shimon Ben-Shabat in 1998. When terpenes, cannabinoids and flavonoids work together in harmony to produce therapeutic effects, the results are more significant than if these compounds were introduced into the body alone.

A Peek into Trans - Nerolidol

Nerolidol is well known for its woody, citrusy aroma that is reminiscent of citrus fruit, apples, and roses. Nerolidol occurs naturally in many strong aromatics like jasmine, tea tree oil, and lemongrass and is well known for its sedative effects.

Nerolidol tends to be a lesser known terpene but packs a powerful punch against stress and anxiety. Nerolidol is known for its fresh bark taste, calming properties and has also been shown to be a toxin against harmful protozoa like malaria and leishmaniasis.

Nerolidol comes in two different isomer forms, cis and trans, which demonstrate differences around the geometry of the central double bond. Trans-Nerolidol is the isomer form typically found in cannabis flowers.

The use of nerolidol is prevalent in many different products, including shampoos, creams, soaps, detergents and cleaners and the Food and Drug Administration (FDA) even approved the essential oil as a food flavouring agent. The use of nerolidol in these products has prompted scientists to study the possible medicinal applications of nerolidol and the role terpenes play in overall health. 

Nerolidol is well known in the medical community for its antiparasitic, antioxidant, antifungal, anti-cancer, and an anti-microbial applications.

The Science Behind Trans - Nerolidol

A study in the Journal of Pharmacy and Pharmacology demonstrated that when applied topically, nerolidol aids in the absorption of other topicals. Furthermore, nerolidol prolonged the action of topically applied medications. This is why nerolidol is so popular in topical beauty products and as an additive to topical pain relievers and creams.

Another study, in the Journal of Ethnopharmacology showed that nerolidol can be used as an anti-malarial drug. Within 48 hours of exposure, 100 micrograms/mL of nerolidol caused 100% growth inhibition of young trophozoite to schizont stage malaria and decreased the expression of the p21 RAS protein. This offers promise for the medical community, as traditional malaria medications tend to come with a laundry list of side-effects.

High-Nerolidol Strains

Nerolidol is present in both sativa and indica strains, although it is more prominent in indica buds which have relaxing, sedative properties. According to Cannabis Wiki some strains historically rich in nerolidol terpenes include:

  • Jack Herer
  • Sour Diesel
  • Skywalker
  • Tangilope
  • Girl Scout Cookies
  • Chem Dawg
  • Blue Dream
  • Black Lime
  • Jaywalker OG
  • Green Mountain
  • Sour Kush
  • Bubba Kush
  • Good Morning
  • Island Sweet Skunk

While your nose may lead you to strains with nerolidol in them, it is always advisable to look at the strain testing information, which generally includes a terpene profile. This will give consumers important information about the effects of the strain, its terpene profile and a list of cannabinoids and their percentages.

Enjoy the Benefits of Trans - Nerolidol with Meraki Tips

Meraki Tips harness the benefits of terpenes by infusing essential oils, such as nerolidol, into terpene-enhanced crutches in order to maximize the potential of each and every cannabis experience. Consumers have a choice between the Sayonara Tip to boost the relaxing properties of their herb, or the Peaceful Tip designed to curb unwanted anxieties that may have cropped up throughout the day. Both tips boast the magic of terpenes that seek to enhance every experience with the cannabis plant.